EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1-6 infection with or without cirrhosis (compensated).
EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1-6 infection with or without cirrhosis (compensated).
While your healthcare provider is the best resource, you can find the answers to some of the most frequently asked questions about EPCLUSA and Hep C below.
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Understanding EPCLUSA
Treatment duration with EPCLUSA is 12 weeks for everyone, no matter your genotype.
Please see Important Facts about EPCLUSA including Important Warnings about hepatitis B reactivation.
The most common side effects of EPCLUSA in adults include headache and tiredness.
EPCLUSA can cause serious side effects, including hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.
Serious side effects may also include:
Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms:
- fainting or near-fainting
- dizziness or lightheadedness
- not feeling well
- weakness
- extreme tiredness
- shortness of breath
- chest pains
- confusion
- memory problems
These are not all the possible side effects of EPCLUSA. For more information, ask your healthcare provider or pharmacist.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Important Facts about EPCLUSA including Important Warnings about hepatitis B reactivation at EPCLUSA.com.
When visiting your healthcare provider, be prepared to share your medical history. It’s a good idea to bring along:
- Your medical records
- A list of any medicines you are taking including:
- Prescription and/or over-the-counter medicines
- Vitamins
- Herbal supplements
- A list of any questions you may have for your healthcare provider
Be prepared to talk about any symptoms you may be experiencing, even if you don’t think they seem related to your liver or Hep C. You may wish to write down this information prior to your visit and bring it with you.
Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects. Also, tell them if you’ve struggled with addiction.
Have an open and honest conversation with your healthcare provider. Tell them if you’re currently taking any medication to treat your addiction, such as methadone, a medication-assisted treatment for addiction.
Treating Hep C is possible in your recovery and could be an important step in your overall health goals. EPCLUSA can be taken with certain medication-assisted treatments. Get connected with a healthcare provider to see if EPCLUSA is right for you.
Also, tell your healthcare provider about all the medicines you take and ask if they will interact with EPCLUSA. EPCLUSA and certain other medicines may affect each other or cause side effects.
No additional medicines are required for the majority of patients. EPCLUSA is one pill, taken once daily, with or without food.
EPCLUSA with ribavirin is recommended for certain patients with advanced cirrhosis (decompensated). If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
Take EPCLUSA exactly as your healthcare provider tells you to take it.
EPCLUSA and certain other medicines may affect each other, or may cause side effects.
Consult your healthcare provider with any treatment questions.
Your healthcare provider can tell you if you can take EPCLUSA with your birth control medication. Do not take any other medications without talking to your healthcare provider first.
EPCLUSA and certain other medicines may affect each other, or may cause side effects. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Even if your previous Hep C treatment was unsuccessful, EPCLUSA may work. In clinical studies, EPCLUSA was proven effective in treating chronic Hep C patients who had previously failed a peginterferon alfa- and ribavirin-based regimen, with or without a protease inhibitor. Protease inhibitors are a class of antiviral drugs used to treat Hep C and work by stopping the virus from replicating. Examples of drugs that are protease inhibitors are Incivek® (telaprevir) and Victrelis® (boceprevir).
Speak with your healthcare provider to find out if EPCLUSA is right for you.
EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.
Speak with your healthcare provider to find out if EPCLUSA is right for you.
If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
If you have cirrhosis, it may not be too late to try EPCLUSA to treat your Hep C.
Treatment with EPCLUSA may cost less than you think and is covered by insurance plans.
For information about ways you could save money on EPCLUSA, visit Financial Assistance & Insurance Support or call 1-855-7-MYPATH (1-855-769-7284).
Please see Important Facts about EPCLUSA including Important Warnings about hepatitis B reactivation at EPCLUSA.com.
One way is by contacting EPCLUSA Support Path®, where a program navigator can assist you with this and other insurance-related questions. Call EPCLUSA Support Path at 1-855-7-MYPATH (1-855-769-7284) and inform the EPCLUSA Support Path program navigator that you want to complete a benefits investigation. Provide the EPCLUSA Support Path® program navigator with your name and address, the name and address of your prescribing doctor, your pharmacy benefit card, and your medical benefit card. You may also contact your insurance company directly.
Speak with a live EPCLUSA Support Path program navigator 1-855-7-MYPATH (1-855-769-7284).
You still might be eligible for financial assistance. Visit Financial Assistance & Insurance Support or speak with an EPCLUSA Support Path® program navigator at 1-855-7-MYPATH (1-855-769-7284) to see what options might be available to you.
Speak with a live EPCLUSA Educator about getting your prescription 1-844-4-EPCLUSA (1-844-437-2587).
If you or your healthcare provider have contacted EPCLUSA Support Path and requested verification of your insurance coverage, you will receive verification of your benefits in a follow-up phone call from EPCLUSA Support Path within 24–48 hours. Your healthcare provider will receive a written benefit verification summary via fax within 48 hours.
Speak with a live EPCLUSA Support Path program navigator 1-855-7-MYPATH (1-855-769-7284).
If you have questions, you should refer to your healthcare provider first. If you need additional support, you can call the EPCLUSA Education Line at 1-844-4-EPCLUSA (1-844-437-2587) Monday-Friday.
Speak with an EPCLUSA Educator if you need more support 1-844-4-EPCLUSA (1-844-437-2587).
Taking EPCLUSA
If you and your healthcare provider decide EPCLUSA is right for you, your healthcare provider will submit your prescription directly to a specialty pharmacy.
Speak with an EPCLUSA Educator about getting your prescription 1-844-4-EPCLUSA (1-844-437-2587).
Specialty pharmacies provide medicines that have special delivery, storage, or administration requirements, and typically deliver them directly to patients by US mail or a delivery service.
Speak with an EPCLUSA Educator about specialty pharmacies 1-844-4-EPCLUSA (1-844-437-2587).
Your EPCLUSA dosing should follow exactly what your healthcare provider tells you.
Don’t stop taking EPCLUSA without first talking with your healthcare provider.
Take 1 EPCLUSA pill each day with or without food.
It’s important that you don’t miss or skip doses of EPCLUSA during treatment.
If you take too much EPCLUSA, call your healthcare provider or go to the nearest hospital emergency room right away.
If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide, including dosing information.
- Store EPCLUSA at room temperature below 86 °F (30 °C)
- Keep EPCLUSA in its original container
- Do not use EPCLUSA if the seal over the bottle opening is broken or missing
Keep EPCLUSA and all medicines out of the reach of children.
It’s important to take EPCLUSA as prescribed by your healthcare provider. If you miss a dose, call your healthcare provider immediately. Missing a dose lowers the amount of medicine in your body. If you take too much EPCLUSA, call your healthcare provider or go to the nearest emergency room right away.
Speak with an EPCLUSA Educator about keeping up with your treatment 1-844-4-EPCLUSA (1-844-437-2587).
Each day, the Hep C virus makes billions of copies of itself in your body. Staying on EPCLUSA for the full course of treatment gives it the best chance to fight the virus. It’s important that you don’t miss or skip doses of EPCLUSA during treatment.
Speak with an EPCLUSA Educator about staying on track 1-844-4-EPCLUSA (1-844-437-2587).
Being “cured” of Hep C is defined as when the virus cannot be detected in the blood when measured at least 3 months after treatment is completed. Your healthcare provider will use a simple blood test to determine your success with treatment.
Speak with an EPCLUSA Educator about protecting your cure 1-844-4-EPCLUSA (1-844-437-2587).
Hep C is mainly spread through blood-to-blood contact. Sharing needles or drug equipment, having sex with someone who has Hep C, or using unsanitary tattoo equipment are all activities that may increase your risk of getting Hep C again.
Speak with an EPCLUSA Educator about protecting your cure 1-844-4-EPCLUSA (1-844-437-2587).

What is EPCLUSA?
EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1-6 infection with or without cirrhosis (compensated).
Important Safety Information
What is the most important information I should know about EPCLUSA?
EPCLUSA can cause serious side effects, including:
- Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.
What should I tell my healthcare provider before taking EPCLUSA?
- Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk.
- Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects.
What are the possible side effects of EPCLUSA?
Serious side effects may also include:
- Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
- The most common side effects of EPCLUSA in adults include headache and tiredness.
These are not all the possible side effects of EPCLUSA. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Important Facts about EPCLUSA including Important Warnings.EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1-6 infection with or without cirrhosis (compensated).
Important Safety Information
What is the most important information I should know about EPCLUSA?
EPCLUSA can cause serious side effects, including:
- Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.
What should I tell my healthcare provider before taking EPCLUSA?
- Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk.
- Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects.
What are the possible side effects of EPCLUSA?
Serious side effects may also include:
- Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
- The most common side effects of EPCLUSA in adults include headache and tiredness.
These are not all the possible side effects of EPCLUSA. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Important Facts about EPCLUSA including Important Warnings.
Important Safety Information
What is the most important information I should know about EPCLUSA?
EPCLUSA can cause serious side effects, including:
- Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.
What should I tell my healthcare provider before taking EPCLUSA?
- Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk.
- Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects.
What are the possible side effects of EPCLUSA?
Serious side effects may also include:
- Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
- The most common side effects of EPCLUSA in adults include headache and tiredness.
These are not all the possible side effects of EPCLUSA. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Important Facts about EPCLUSA including Important Warnings.