FAQ

EPCLUSA is a prescription medicine used to
treat adults with chronic hepatitis C (Hep C)
genotype 1-6 infection with or without cirrhosis
(compensated).

Important Safety Information

What is the most important information I
should know about EPCLUSA?

What is the most important
information I should know about
EPCLUSA?

EPCLUSA can cause serious side effects, including:

EPCLUSA can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting
    EPCLUSA treatment, your healthcare provider will
    do blood tests to check for hepatitis B infection. If
    you have ever had hepatitis B, the hepatitis B virus
    could become active again during and after
    treatment with EPCLUSA. This may cause serious
    liver problems including liver failure and death. If
    you are at risk, your healthcare provider will monitor
    you during and after taking EPCLUSA.

    Hepatitis B virus reactivation:
    Before starting EPCLUSA treatment,
    your healthcare provider will do blood
    tests to check for hepatitis B infection.
    If you have ever had hepatitis B, the
    hepatitis B virus could become active
    again during and after treatment with EPCLUSA. This may cause serious liver
    problems including liver failure and
    death. If you are at risk, your
    healthcare provider will monitor you
    during and after taking EPCLUSA.

See complete Important Safety
Information below

While your healthcare provider is the best resource, you can find the answers to some of the most frequently asked questions about EPCLUSA and Hep C below.

Want to talk to a person instead?

What are the possible side effects of EPCLUSA (sofosbuvir/velpatasvir)?

Please see Important Facts about EPCLUSA including Important Warning about hepatitis B reactivation.

The most common side effects of EPCLUSA in adults include headache and tiredness.

EPCLUSA can cause serious side effects, including Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.

Serious side effects may also include:

Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms:

  • fainting or near-fainting

  • dizziness or lightheadedness

  • not feeling well

  • weakness

  • extreme tiredness

  • shortness of breath

  • chest pains

  • confusion

  • memory problems

  • shortness of breath
  • chest pains
  • confusion
  • memory problems

These are not all the possible side effects of EPCLUSA. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Important Facts about EPCLUSA including Important Warning about hepatitis B reactivation on EPCLUSA.com.

What should I bring with me when I visit my Hep C doctor?

When visiting your Hep C Specialist, be prepared to share your medical history. It’s a good idea to bring along:

  • Your medical records

  • A list of any medicines you are taking including:

  • Prescription and/or
    over-the-counter medicines

  • Vitamins

  • Herbal supplements

  • A list of any questions you may have for your Hep C Specialist

Be prepared to talk about any symptoms you may be experiencing, even if you don’t think they seem related to your liver or Hep C. You may wish to write down this information prior to your visit and bring it with you.

Icon of a female Hep C patient

What should I tell my healthcare provider before taking EPCLUSA?

Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects. Also, tell them if you’ve struggled with addiction.

Icon of a female Hep C patient

What if I had previously struggled with drug addiction?

Have an open and honest conversation with your healthcare provider. Tell your doctor if you’re currently taking any medication to treat your addiction, such as methadone, a medication-assisted treatment for addiction.

Does EPCLUSA need to be taken with other medicines to treat Hep C?

No additional medicines are required for the majority of patients. EPCLUSA is one pill, taken once daily, with or without food.

EPCLUSA with ribavirin is recommended for certain patients with advanced cirrhosis (decompensated). If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

Take EPCLUSA exactly as your healthcare provider tells you to take it.

EPCLUSA and certain other medicines may affect each other, or may cause side effects.

Consult your healthcare provider with any treatment questions.

Can I take EPCLUSA if I was not cured with a previous Hep C treatment?

Even if your previous Hep C treatment was unsuccessful, EPCLUSA may work. In clinical studies, EPCLUSA was proven effective in treating chronic Hep C patients who had previously failed a peginterferon alfa- and ribavirin-based regimen, with or without a protease inhibitor. Protease inhibitors are a class of antiviral drugs used to treat Hep C and work by stopping the virus from replicating. Examples of drugs that are protease inhibitors are Incivek® (telaprevir) and Victrelis® (boceprevir).

Speak with your Hep C Specialist to find out if EPCLUSA is right for you.

Can I take EPCLUSA if I have cirrhosis?

EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

Speak with your Hep C Specialist to find out if EPCLUSA is right for you.

If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

If you have cirrhosis, it may not be too late to try EPCLUSA to treat your Hep C.

Are there ways I could save money on EPCLUSA (sofosbuvir/velpatasvir)?

Treatment with EPCLUSA may cost less than you think and is covered by most insurance plans.

For information about ways you could save money on EPCLUSA, visit Financial Assistance & Insurance Support or call 1-855-7-MYPATH (1-855-769-7284).

Please see Important Facts about EPCLUSA including Important Warning about hepatitis B reactivation on EPCLUSA.com.

Young male Hep C patient with car icon

How do I find out if my insurance covers EPCLUSA?

One way is by contacting EPCLUSA Support Path®, where a program navigator can assist you with this and other insurance-related questions. Call EPCLUSA Support Path at 1-855-7-MYPATH (1-855-769-7284) and inform the EPCLUSA Support Path program navigator that you want to complete a benefits investigation. Provide the EPCLUSA Support Path program navigator with your name and address, the name and address of your prescribing doctor, your pharmacy benefit card, and your medical benefit card. You may also contact your insurance company directly.

How long will it take to receive verification of my benefits from EPCLUSA Support Path®?

If you or your healthcare provider have contacted EPCLUSA Support Path and requested verification of your insurance coverage, you will receive verification of your benefits in a follow-up phone call from EPCLUSA Support Path within 24–48 hours. Your healthcare provider will receive a written benefit verification summary via fax within 48 hours.

Single pill icon Pill not actual size.

How should I take EPCLUSA?

Your EPCLUSA dosing should follow exactly what your healthcare provider tells you.

Don’t stop taking EPCLUSA without first talking with your healthcare provider.

Take 1 EPCLUSA pill each day with or without food.

It’s important that you don’t miss or skip doses of
EPCLUSA during treatment.

If you take too much EPCLUSA, call your healthcare provider or go to the nearest hospital emergency room right away.

If you take EPCLUSA with ribavirin, you should also read the Medication Guide for ribavirin, including dosing information.

pill-icon Pill not actual size.

How should I store EPCLUSA?

  • Store EPCLUSA at room temperature below 86 °F (30 °C)

  • Keep EPCLUSA in its original container

  • Do not use EPCLUSA if the seal over the bottle opening is broken or missing

Keep EPCLUSA and all medicines out of the reach of children.

What if I miss a dose of EPCLUSA?

It’s important to take EPCLUSA as prescribed by your healthcare provider. If you miss a dose, be sure to take EPCLUSA the very next day. Never take more than one EPCLUSA pill per day. If you take too much EPCLUSA, call your healthcare provider or go to the nearest emergency room right away.

Icon of a female Hep C patient

Why is it important to stay on EPCLUSA for the full time?

Each day, the Hep C virus makes billions of copies of itself in your body. Staying on EPCLUSA for the full time gives it the best chance to fight the virus. It’s important that you don’t miss or skip doses of EPCLUSA during treatment.

After I have finished treatment, how long will it take to find out if I’m cured?

Being “cured” of Hep C is defined as when the virus cannot be detected in the blood when measured at least 3 months after treatment is completed. Your doctor will use a simple blood test to determine your success with treatment.

How can I avoid getting Hep C again?

Hep C is mainly spread through blood-to-blood contact. Sharing needles or drug equipment, having sex with someone who has Hep C, or using unsanitary tattoo equipment are all activities that may increase your risk of getting Hep C again.

Icon of a young female Hep C patient
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Pay as little as

$5 per co-pay.
Restrictions apply.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about EPCLUSA?

EPCLUSA can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.

  • What should I tell my healthcare provider before taking EPCLUSA?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk.

    Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects.

  • What are the possible side effects of EPCLUSA?

    Serious side effects may also include:

  • Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

  • The most common side effects of EPCLUSA in adults include headache and tiredness.

  • The most common side effects of EPCLUSA in adults include headache and tiredness. The most common side effects of EPCLUSA when used with ribavirin in adults with decompensated cirrhosis are tiredness, low red blood cells, nausea, headache, trouble sleeping, and diarrhea.

  • These are not all the possible side effects of EPCLUSA. Call your doctor for medical advice about side effects.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

    What is EPCLUSA?

    EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1-6 infection with or without cirrhosis (compensated).

    EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1-6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

    Please see Important Facts about EPCLUSA including Important Warning.

    Tap for Important Safety Information about EPCLUSA including Important Warning on hepatitis B reactivation.