Preparing for
your next steps

Whether you already have a prescription for EPCLUSA or are just considering it, you may be wondering what you need to do next. Use the tool below to see some of the key next steps that lie ahead and how you can prepare for them.

EPCLUSA is a prescription medicine used to treat adults with chronic hepatitis C genotypes 1–6 infection without cirrhosis or with compensated cirrhosis.

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I’m interested in EPCLUSA but not currently seeing a Hep C Specialist.
I’m seeing a Hep C Specialist but haven’t been prescribed EPCLUSA.
I’ve been prescribed EPCLUSA.
  • Find a Hep C Specialist

    If you’re tired of living with the uncertainties of Hep C, talking with a Hep C Specialist is a great place to start. You are your best advocate throughout the EPCLUSA treatment process, but working with a Hep C Specialist means you’ve got an expert on your side.

    With special training in Hep C treatment, Hep C Specialists are among the most informed about the latest developments in the field. Hep C Specialists include, but are not limited to, gastroenterologists (specialists in diseases that affect the digestive system) and hepatologists (specialists in diseases that affect the liver). Others who may treat Hep C include infectious diseases (ID) specialists, primary care physicians (PCPs), internal medicine specialists (internists), nurse practitioners (NPs), and physician assistants (PAs).

    Not only may it be to your advantage to work with a Hep C Specialist because of their expertise, some insurance providers will only approve EPCLUSA prescriptions written by a Hep C Specialist.

    To find a Hep C Specialist near you, enter your ZIP code:

    Once you’ve found a Hep C Specialist, it’s time to make an appointment and plan for your conversation.

    Next: Make the most of your appointment

  • Make the most of your appointment

    Patients and healthcare providers alike understand that good communication can improve quality of care. When you go in for your appointment with your Hep C Specialist, make sure you’re having as productive a conversation as possible.

    Be ready to work closely with your Hep C Specialist. There are many factors to discuss to help your Hep C Specialist determine if EPCLUSA could be right for you, including:

    • The type of Hep C you have, called your genotype (If you have Hep C genotype 1, 4, 5, or 6, learn about another treatment option that may be right for you.)
    • The extent of damage to your liver
    • Any symptoms you may be experiencing

    Express yourself and be clear—let your specialist know that you’re ready to find out if EPCLUSA is right for you.

    Prepare for your appointment.

    Download your conversation guide

    Once you feel ready to make the most of your Hep C Specialist appointment, it’s time to explore your insurance coverage—even before you go to your appointment.

    Next: Understand your insurance benefits

  • Understand your insurance benefits

    If you’ve been prescribed EPCLUSA, your next step will likely be to focus on your insurance coverage. The more you know about your coverage options could make the benefits process easier down the line. Even if you think your insurance won’t cover EPCLUSA—or if you’re uninsured altogether—there may be solutions out there that would still allow you to receive EPCLUSA.

    Knowing that coverage options may be available is one thing, but finding them and figuring them out is another. That’s where the live program navigators at EPCLUSA Support Path® come in. They work with people in your position every day and are experts in finding ways to make coverage for treatment with EPCLUSA possible.

    Live EPCLUSA Support Path navigators can walk you through your plan and perform a benefits investigation, where they’ll find out if your insurance covers EPCLUSA. What’s more, they can prepare you for the coming approval process (which may require a process known as prior authorization) and give you a sense of what your out-of-pocket costs may be.

    To get started, call EPCLUSA Support Path at 1-855-7-MYPATH (1-855-769-7284) and tell the EPCLUSA Support Path navigator that you have a prescription for EPCLUSA and want to complete a benefits investigation.

    Learn more about navigating your insurance and completing a benefits investigation.

    Visit Financial Assistance & Insurance Support

    Once you’ve gotten a handle on your insurance coverage, your next step is to look into ways you can reduce your out-of-pocket treatment costs.

    Next: Manage out-of-pocket costs

  • Manage out-of-pocket costs

    Focusing on your health is demanding enough without worrying about financial concerns. If you and your Hep C Specialist have decided that EPCLUSA is right for you, financial assistance may be available.

    Call 1-855-7-MYPATH (1-855-769-7284) and speak with an EPCLUSA Support Path® program navigator about all of the ways you may be able to keep out-of-pocket costs down.

    You may be eligible to keep costs down with the EPCLUSA co-pay coupon, which may allow you to pay no more than $5 per co-pay. Most people with private insurance are eligible.

    You are not eligible if you are enrolled in a government healthcare prescription drug program such as Medicaid or Medicare Part D (including when you are in the coverage gap known as the “donut hole”). To learn more, visit Financial Assistance & Insurance Support.

    If you are eligible, the EPCLUSA Co-pay Coupon Program will cover the out-of-pocket costs of your EPCLUSA prescriptions up to a maximum of 25% of the catalog price of a 12-week regimen of EPCLUSA.

    See if you’re eligible to pay no more than $5 per co-pay.

    Register for the
    EPCLUSA co-pay coupon

    Once you’ve explored ways to keep costs down, you’re ready to focus on staying on track with treatment.

    Next: Get support to help stay on track

  • Get support to help stay on track

    If you’ve completed all of the steps to get ready for treatment with EPCLUSA, it’s time to focus on treatment itself. Look to support from EPCLUSA to help you reach your goals.

    Live nurse support
    If you have any questions about your treatment at any point, speak with your Hep C Specialist or call our live nurse hotline. Having a live person to talk to can make all the difference.

    To connect with a nurse, call 1-844-4-EPCLUSA (1-844-437-2587)


    Any other questions about EPCLUSA?
    Visit FAQs

EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

Important Safety Information

What is the most important information I should know about EPCLUSA?

EPCLUSA can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.

What should I tell my healthcare provider before taking EPCLUSA?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection or liver problems other than hepatitis C infection; if you have severe kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects.

What are the possible side effects of EPCLUSA?

Serious side effects may also include:

  • Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

The most common side effects of EPCLUSA include headache and tiredness. Tell your healthcare provider if you have any side effect that bothers you or does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Please see Important Facts about EPCLUSA including Important Warning.