ASK AWAY

Don’t let your questions slow you down—let their answers help you get going. Your Hep C Specialist is a great resource for any information regarding Hep C or treatment with EPCLUSA, or you may be able to get the help you need from the frequently asked questions and their answers below.

If you require further assistance, speak with an EPCLUSA Educator at 1-844-4-EPCLUSA (1-844-437-2587), or contact your Hep C Specialist.

EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

UNDERSTANDING HEP C

ABOUT EPCLUSA

TREATMENT WITH EPCLUSA

  • UNDERSTANDING HEP C

    Get the facts about hepatitis C, including symptoms, effects, and the importance of genotype.

    • What is hepatitis C (Hep C) and what effects can it have?

      Hepatitis C is a contagious liver disease that ranges in severity from a mild illness lasting a few weeks to a serious, lifelong illness that attacks the liver. It results from infection with the hepatitis C virus (HCV), which is spread through contact with the blood of an infected person. Most people who become infected with the Hep C virus go on to develop chronic (or long-lasting) Hep C. Chronic Hep C progresses slowly and over time can cause liver damage or cirrhosis.

      If you have Hep C, you should work with your healthcare provider to assess your liver damage and discuss your treatment options before it progresses.

      To learn more about how Hep C affects your liver health, sign up for Onward™ and get free step-by-step guidance and information about Hep C.

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      What are the symptoms of Hep C?

      Called a “silent disease,” Hep C symptoms often do not appear or can be quite mild for years or even decades, even while liver damage is taking place. Most people with the Hep C virus go on to develop chronic Hep C and still have no symptoms or signs. Common symptoms of chronic Hep C can include fever, tiredness, loss of appetite, nausea, vomiting, dark urine, abdominal pain, joint pain, gray-colored stools, and jaundice (yellowing of skin or eyes).

      If you'd like to learn more about Hep C symptoms, sign up for Onward™ and get free step-by-step guidance and information about treating your Hep C.

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      What is a Hep C genotype and why is this important?

      Just as there are different blood types, there are also different types of Hep C, called genotypes. It is important to know your genotype because it can help your healthcare provider choose the right treatment for you. Your healthcare provider can do a simple blood test to determine your Hep C genotype. EPCLUSA is used to treat chronic Hep C genotype 1, 2, 3, 4, 5, or 6.

      Want to learn more?

      VISIT CLINICAL STUDY RESULTS

      If you have Hep C genotype 1, 4, 5, or 6, learn about another treatment option that may be right for you.

  • ABOUT EPCLUSA

    Find out general information about EPCLUSA, including dosing, side effects, and impact of previous Hep C treatment.

    • What is EPCLUSA?

      EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

      If you have Hep C genotype 1, 4, 5, or 6, learn about another treatment option that may be right for you.

      Want to learn more about EPCLUSA? Sign up for Onward™ and get free step-by-step guidance to help you get started.

      MOVE ONE STEP CLOSER
      How long does therapy with EPCLUSA last?

      Treatment duration with EPCLUSA is 12 weeks. Your Hep C Specialist will determine your treatment regimen based on your individual case.

      Want to know more about treatment with EPCLUSA? Learn more here.

      Not currently working with a Hep C Specialist? Find one here.

      Sign up for Onward™ to learn more about treatment with EPCLUSA and get free step-by-step guidance to help you get started.

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      How should I take EPCLUSA?

      Take EPCLUSA exactly as your healthcare provider tells you to take it. Do not change your dose unless your healthcare provider tells you to.

      Do not stop taking EPCLUSA without first talking with your healthcare provider.

      Take 1 EPCLUSA tablet each day.

      Take EPCLUSA with or without food.

      It is important that you do not miss or skip doses of EPCLUSA during treatment.

      If you take too much EPCLUSA, call your healthcare provider or go to the nearest hospital emergency room right away.

      Want to learn more?

      VISIT TAKING EPCLUSA
      What is the most important information I should know about EPCLUSA?

      EPCLUSA can cause serious side effects, including:

      • Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.
      What should I tell my healthcare provider before taking EPCLUSA?
      • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection or liver problems other than hepatitis C infection; if you have severe kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
      • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects.

      Need more help preparing to speak with your Hep C Specialist?

      DOWNLOAD YOUR
      CONVERSATION GUIDE
      Does EPCLUSA need to be taken with other medicines to treat Hep C?

      No additional medicines are required for the majority of patients. EPCLUSA is one pill, taken once daily, with or without food.

      EPCLUSA with ribavirin is recommended for certain patients with advanced cirrhosis (decompensated). If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

      Take EPCLUSA exactly as your healthcare provider tells you to take it.

      EPCLUSA and certain other medicines may affect each other, or may cause side effects.

      Consult your Hep C Specialist with any treatment questions.

      Need more help preparing to speak with your Hep C Specialist?

      DOWNLOAD YOUR
      CONVERSATION GUIDE
      What are the possible side effects of EPCLUSA?

      EPCLUSA can cause serious side effects, including:

      • Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.

      Serious side effects may also include:

      • Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms:
        • - fainting or near-fainting
        • - dizziness or lightheadedness
        • - not feeling well
        • - weakness
        • - extreme tiredness
        • - shortness of breath
        • - chest pains
        • - confusion
        • - memory problems

      The most common side effects of EPCLUSA include:

      • headache
      • tiredness

      Tell your healthcare provider if you have any side effect that bothers you or does not go away.

      These are not all the possible side effects of EPCLUSA. For more information, ask your healthcare provider or pharmacist.

      Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

      Sign up for Onward™ and get personalized treatment tips and free step-by-step guidance to help manage side effects.

      MOVE ONE STEP CLOSER
      Can I take EPCLUSA if I was not cured with a previous Hep C treatment? (Cure means the Hep C virus is not detected in the blood when measured three months after treatment is completed.)

      In clinical studies, EPCLUSA has been proven effective in patients with Hep C who were unsuccessful with past Hep C treatment. In these studies, treatment-experienced patients were those who had failed a peginterferon alfa and ribavirin based regimen with or without an HCV protease inhibitor. (Protease inhibitors are a class of antiviral drugs used to treat Hep C and work by stopping the virus from replicating. Examples of drugs that are protease inhibitors are Incivek® [telaprevir] and Victrelis® [boceprevir].)

      Speak with your Hep C Specialist to find out if EPCLUSA is right for you.

      If you were previously treated for Hep C with something other than peginterferon alfa and ribavirin, with or without a protease inhibitor, learn about another treatment option that may be right for you.

      If you have Hep C genotype 1, 4, 5, or 6, learn about another treatment option that may be right for you.

      Thinking about treating your Hep C again? Sign up for Onward™ and get free step-by-step guidance to help you get started.

      MOVE ONE STEP CLOSER
      Can I take EPCLUSA if I have cirrhosis?

      EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

      Speak with your Hep C Specialist to find out if EPCLUSA is right for you.

      If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

      If you have cirrhosis, it may not be too late to try EPCLUSA to treat your Hep C. Sign up for Onward™ and get free step-by-step guidance to help you get started.

      MOVE ONE STEP CLOSER
  • TREATMENT WITH EPCLUSA

    Learn about filling your prescription, understanding insurance coverage, exploring ways to keep out-of-pocket costs down, and more.

    • Why is it important that I work with a Hep C Specialist?

      Partnering up with a Hep C Specialist means you’ve got an expert on your side.

      Hep C Specialists are equipped to tell you about all of the treatment options that are available to you. Hep C Specialists include, but are not limited to, gastroenterologists (specialize in diseases that affect the digestive system) and hepatologists (specialize in diseases that affect the liver). Others who may treat Hep C include infectious diseases (ID) specialists; primary care physicians (PCPs), internal medicine specialists (internists) or family doctors; nurse practitioners (NPs), and physician assistants (PAs).

      Not currently working with a Hep C Specialist?

      FIND A HEP C SPECIALIST
      What should I bring with me when I visit my Hep C Specialist?

      When visiting your Hep C Specialist, be prepared to share your medical history. It's a good idea to bring along your medical records, a list of any and all medicines you are taking (prescription and/or over-the-counter medicines, vitamins, and herbal supplements), and a list of any questions you may have for your Specialist. Be prepared to talk about any symptoms you may be experiencing, even if you don’t think they seem related to your liver or hepatitis C. You may wish to write down this information prior to your visit and bring it with you.

      Need more help preparing to speak with your Hep C Specialist?

      DOWNLOAD YOUR
      CONVERSATION GUIDE
      How does my Hep C Specialist determine my EPCLUSA treatment plan?

      Treatment duration with EPCLUSA is 12 weeks. Your Hep C Specialist will determine your treatment regimen based on your individual case. He or she will likely consider:

      For patients with advanced cirrhosis (decompensated) and Hep C genotype 1–6, EPCLUSA plus ribavirin provides an all-oral treatment option with just 12 weeks of therapy. Your Hep C Specialist will determine the regimen that’s right for you.

      If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

      If you were previously treated for Hep C with something other than peginterferon alfa and ribavirin, with or without a protease inhibitor, learn about another treatment option that may be right for you. (Protease inhibitors are a class of antiviral drugs used to treat Hep C and work by stopping the virus from replicating. Examples of drugs that are protease inhibitors are Incivek® [telaprevir] and Victrelis® [boceprevir].)

      Want to learn more?

      VISIT TAKING EPCLUSA
      How do I fill my EPCLUSA prescription?

      If you and your Hep C Specialist decide EPCLUSA is right for you, your Hep C Specialist will submit your prescription directly to a specialty pharmacy. Specialty pharmacies provide medications that have special delivery, storage, or administration requirements, and typically deliver medicine directly to patients by US mail or a delivery service.

      Want to learn more? Speak with an EPCLUSA Support Path® specialist at 1-855-7-MYPATH (1-855-769-7284).

      What is a specialty pharmacy?

      Specialty pharmacies provide medications that have special delivery, storage, or administration requirements, and typically deliver medicine directly to patients by US mail or a delivery service.

      Want to learn more? Speak with an EPCLUSA Support Path® specialist at 1-855-7-MYPATH (1-855-769-7284).

      Are there ways I could save money on EPCLUSA?

      For information about ways you could save money on EPCLUSA, visit Financial Assistance & Insurance Support or call 1-855-7-MYPATH (1-855-769-7284).

      You may be eligible to pay no more than $5 per co-pay for EPCLUSA. Restrictions apply.

      CHECK YOUR ELIGIBILITY FOR
      AN EPCLUSA CO-PAY COUPON
      How do I find out if my insurance covers EPCLUSA?

      One way is by contacting EPCLUSA Support Path®, where a specialist can assist you with this and other insurance-related questions. Call EPCLUSA Support Path at 1-855-7-MYPATH (1-855-769-7284) and inform the EPCLUSA Support Path specialist that you want to complete a benefits investigation. Provide the EPCLUSA Support Path specialist with your name and address, the name and address of your prescribing doctor, your pharmacy benefit card, and your medical benefit card. You may also contact your insurance company directly.

      Need more help preparing for your benefits investigation?

      VISIT FINANCIAL ASSISTANCE & INSURANCE SUPPORT
      How long will it take to receive verification of my benefits from EPCLUSA Support Path®?

      If you or your healthcare provider have contacted EPCLUSA Support Path and requested verification of your insurance coverage, you will receive verification of your benefits in a follow-up phone call from EPCLUSA Support Path within 24–48 hours. Your physician will receive a written benefit verification summary via fax within 48 hours.

      Need more help navigating your insurance coverage?

      VISIT FINANCIAL ASSISTANCE & INSURANCE SUPPORT
      What if my insurance doesn’t cover EPCLUSA?

      You still might be eligible for financial assistance. Visit Financial Assistance & Insurance Support or speak with an EPCLUSA Support Path® specialist at 1-855-7-MYPATH (1-855-769-7284) to see what options might be available to you.

      After I have finished treatment, how long will it take to find out if I am cured?

      Being “cured” of Hep C is defined as when the virus cannot be detected in the blood when measured at least three months after treatment is completed. Your doctor will use a simple blood test to determine your success with treatment.

      Want to learn more?

      VISIT TAKING EPCLUSA
      How should I store EPCLUSA?
      • Store EPCLUSA at room temperature below 86°F (30°C).
      • Keep EPCLUSA in its original container.
      • Do not use EPCLUSA if the seal over the bottle opening is broken or missing.

      Keep EPCLUSA and all medicines out of the reach of children.

       
      Need more help? Sign up for Onward™ and get personalized treatment tips and free step-by-step guidance for taking EPCLUSA.

      MOVE ONE STEP CLOSER

EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

Important Safety Information

What is the most important information I should know about EPCLUSA?

EPCLUSA can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.

What should I tell my healthcare provider before taking EPCLUSA?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection or liver problems other than hepatitis C infection; if you have severe kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects.

What are the possible side effects of EPCLUSA?

Serious side effects may also include:

  • Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

The most common side effects of EPCLUSA include headache and tiredness. Tell your healthcare provider if you have any side effect that bothers you or does not go away.

Please see Important Facts about EPCLUSA including Important Warning.